Blocking Effect of J Chain and J-Chain Antibody on the Binding of Secretory Component to Human IgA and IgM
- 1 December 1975
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 4 (8) , 837-842
- https://doi.org/10.1111/j.1365-3083.1975.tb03725.x
Abstract
Isolated released J chain showed only a small affinity for free secretory component (SC), as indicated by a marginal but reproducible blocking effect on the binding of SC to Ig polymers. The SC‐binding site was completely blocked by J‐chain antibody in those Ig polymers where the bound J chains were accessible to the antibody. Along with the established masking effect of SC on the antigenicity of J chains present in secretory IgA, these results are compatible with the idea that the conformation of Ig‐associated J chains contributes to the SC‐binding site of Ig polymers.Keywords
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