Quantitative structure‐activity correlation of pyrethroids againstMusca domesticaandBlattella germanica

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Abstract
Structure‐activity correlations of pyrethroids toMusca domesticaandBlattella germanicawere studied in terms of partition coefficient, electronic effect and conformation. RelativeRfvalues of 12 pyrethroids measured by thin‐layer chromatography were related to the relative partition coefficients and electronic effect. The relative size and shape of six pyrethroids were determined by probabilistic automatic pattern analysis using Corey‐Paulings' molecular models. There is no correlation of knockdown ofM. domesticaand partitioning. The simple correlation, with 0.10<P<0.01 of partitioning, electronic effect and size and shape of pyrethroids to toxicity were 0, 0.2–0.3, 0.7–0.8 respectively while thermodynamic treatment gave corresponding correlations of 0, 0.4, 0.6.