ALLOGENEIC LYMPHOCYTE CYTO-TOXICITY IN RATS - THE EFFECTS OF VARIOUS PHARMACOLOGICAL AGENTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 53  (1) , 43-53
Abstract
In a number of strain combinations among inbred rats, i.v. injected 51Cr-labeled lymphocytes are rapidly destroyed by unsensitized allogeneic hosts. This phenomenon has previously been referred to by a number of terms, the most explicit and least confusing of which is allogeneic lymphocyte cytotoxicity (ALC). It is characterized by reduced lymph node radioactivity, together with increased kidney and/or urine radioactivity 24 h after injection, in allogeneic hosts as compared with syngeneic recipients of the same cell suspension. ALC has a number of features in common with other natural resistance systems. The administration of hydrocortisone or silica in doses comparable to those causing diminished NK [natural killer] activity in rats was without effect on ALC; likewise cyclophosphamide at a dose capable of significantly impairing NK activity in rats had, at most, a minor effect on ALC. Under the conditions of administration cyclosporin A was without effect. The interferon inducer poly I:C brought about a significant augmentation of ALC.