Prenatal Management and Congenital Toxoplasmosis

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Abstract
To the Editor: McCabe and Remington,1 in their editorial on an article by Daffos et al. (Feb. 4 issue),2 propose routine serologic screening of pregnant women to detect and manage toxoplasmosis, but fail to appreciate a number of limitations.In contrast to the situation in France, where the seroconversion rate is about 10 per 1000,3 the seroconversion rate during pregnancy in the United States is about 2 to 6 per 1000.4 This low prevalence diminishes the predictive value of a positive test. If one assumed that both the sensitivity and specificity of the test were 99 percent (i.e., almost "perfect" . . .

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