HEPATIC BLOOD-FLOW STUDIES IN RAT BEFORE AND AFTER PORTACAVAL TRANSPOSITION

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (1) , 8-12
Abstract
Portacaval transposition diverts portal blood from the liver and allows systemic venous blood from the caudal inferior vena cava to perfuse the portal bed. Measurement of hepatic tissue blood flow before and after portacaval transposition and its relationship to the liver atrophy seen after portacaval transposition is important. Sequential measurements of hepatic tissue blood flow carried out before and after portacaval transposition have been made using the clearance of the inert radioactive gas 85Kr after injection into the portal bed. These measurements reveal that hepatic tissue blood flow is not diminished following the operation. The relative liver atrophy seen after portacaval transposition is consequent on portal venous diversion but not on diminished hepatic perfusion.