Effects of nitric oxide synthesis inhibition on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in the rat brain
- 1 June 1996
- journal article
- basic neurosciences-and-genetics
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 103 (6) , 671-680
- https://doi.org/10.1007/bf01271227
Abstract
We examined effects of nitric oxide (NO·) synthesis inhibition on methamphetamine (MA)-induced dopaminergic and serotonergic neurotoxicity. The toxic dose of MA (5 mg/kg, sc, X4) significantly decreased contents of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum (ST), and significantly decreased contents of serotonin (5-HT) in the ST, nucleus accumbens (NA) and medial frontal contex (MFC). Coadministration with a NO· synthase inhibitor, Nω-nitro-L-arginine methyl ester (LNAME) (30 mg/kg, ip, X2), reduced the MA-induced decreases in contents of DA, DOPAC and HVA in the ST, but not reduced the MA-induced decreases in contents of 5-HT in the ST, NA and MFC. These findings suggest that the MA-induced dopaminergic, but not serotonergic neurotoxicity, may be related to the neural process such as NO· formation caused by the activation of postsynaptic DA receptor.Keywords
This publication has 44 references indexed in Scilit:
- Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regionsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1993
- Nitric oxide synthase induction in glial cells: Effect on neuronal survivalLife Sciences, 1993
- Blockade of nitric oxide formation by Nω-nitro-l-arginine mitigates ischemic brain edema and subsequent cerebral infarction in ratsNeuroscience Letters, 1992
- A novel neuronal messenger molecule in brain: The free radical, nitric oxideAnnals of Neurology, 1992
- Nitric Oxide: First in a New Class of NeurotransmittersScience, 1992
- Nitric oxide, a novel neuronal messengerNeuron, 1992
- Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophagesBiochemical and Biophysical Research Communications, 1991
- Dopaminergic modulation of excitotoxicity in rat striatum: Evidence from nigrostriatal lesionsSynapse, 1991
- Glutamate, nitric oxide and cell-cell signalling in the nervous systemTrends in Neurosciences, 1991
- Localization of nitric oxide synthase indicating a neural role for nitric oxideNature, 1990