Managing systemic mycoses in the compromised host

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Abstract
Infection secondary to impaired resistance is the major cause of morbidity and mortality in patients treated with immunosuppressive agents. Fatal infections (commonly Candida spp., C. albicans, Cryptococcus spp., Cr. neoformans and Aspergillus) following immunosuppression are seen most often in cancer and transplantation patients. The incidence of infection is greatest in those receiving steroids, antilymphocyte serum and combination antineoplastic chemotherapy. The problems of diagnosis and management of these infections are discussed. Therapy with amphotericin B, and in some cases flucytosine, is the treatment of choice in most infections.

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