THE NATURE OF INSULIN DERIVED FROM AN ISLET CELL ADENOMA OF THE PANCREAS

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Abstract
The chemical nature of insulin in islet cell tumours of the pancreas has recently been the subject of some discussion. Thus it has been suggested that such insulin does not react with fluorescent antibody (Lacey & Williamson, 1960). Nevertheless, the A-chain derived from insulin which had been obtained from another such tumour has been reported to have an amino acid composition identical with the A-chain derived from human pancreatic insulin (L. F. Smith, personal communication). There is clearly a need for further investigation of the characteristics of insulin present in tumours of this kind. Some of the chemical and immunological properties of the insulin extracted from another such tumour are given below. The patient, a 13-year-old girl, was transferred from a psychiatric hospital after attacks of altered consciousness had been observed to be associated with low blood sugar levels. Six hours after the ingestion of 50g. glucose, the blood sugar

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