Hypothalamic Responses During and Following Occlusion of Cephalic Vasculature in the Cat

Abstract
Classical anemic decerebration in the cat resulted in variable changes in muscle tone and pupillary size. In some animals the light reflex and blood pressure responses to hypothalamic stimulation were observed to persist for significant periods of time. These results indicate that the method is not reliable in obliterating the blood supply to the rostral brain stem. More thorough ligation of cerebral vessels was shown to produce a much greater degree of success as shown by the uniformly prompt increase in extensor tone and pupillary size and the rapid disappearance of light reflexes and hypothalamic responses. The recovery of hypothalamic activity subsequent to periods of almost complete ischemia as long as 1 hour suggests that the region is very resistant to irreversible change if even a small fraction of its normal blood supply is maintained.

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