The Effect Of Antisera In Protecting Pigs Against Experimental Escherichia Coli Diarrhoea And Oedema Disease

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Abstract
Parenteral administration of antiserum usually prevented pigs developing diarrhoea or oedema disease after experimental oral infection with entero-pathogenic strains of Escherichia coli, provided the antiserum had been prepared against the strain of E. coli used to produce the infection. The protection appeared to be principally bactericidal in nature. The antisera might also have had a protective effect against oedema disease that was not strain-specific, presumably by neutralising the metabolites of E. coli that cause this disease.

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