Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis
- 1 March 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 318 (2) , 125-128
- https://doi.org/10.1016/0014-5793(93)80005-f
Abstract
Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4-hydroxy-l-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-l-threonine is implicated in the biosynthesis of vitamin B6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-l-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol.Keywords
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