Selective and Non‐Selective Beta‐Blockade in Renin Release

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Abstract
The effects of 2 .beta.-adrenergic receptor blocking drugs, the nonselective propranolol and the .beta.1 selective metoprolol, were studied on hemodynamics and plasma renin activity (PRA) of healthy volunteers in an ergometric exercise test. Oral doses of 160 mg of propranolol and 200 mg of metoprolol were tested against placebo. Drug plasma concentrations were determined. Heart rate and systolic blood pressure were equal and significantly lower during treatment with both active drugs when compared to placebo. The effect of drugs on exercise heart rate was correlated with the log of drug plasma concentration with propranolol and metoprolol. Propranolol, but not metoprolol, decreased the basal level of PRA. Ergometric exercise induced a significant rise in PRA after placebo, but this increase was partially inhibited by both active drugs. In man the basal level of PRA probably could be decreased mainly by blocking the .beta.2-adrenoceptors. Instead the exercise induced increase of PRA could be inhibited by blocking the .beta.1-adrenergic receptors.