No Adverse Impact on Protection against Pertussis from Combined Administration of Haemophilus infiuenzae Type b Conjugate and Diphtheria-Tetanus Toxoid-Pertussis Vaccines in the Same Syringe
Open Access
- 1 December 1996
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 174 (6) , 1341-1344
- https://doi.org/10.1093/infdis/174.6.1341
Abstract
To assess whether combining a Haemophilus influenzae type b conjugate vaccine (PRP-T) and diphtheria- tetanus toxoid - pertussis (DTP) vaccine in a single syringe would impact adversely the antibody response and clinical protection conferred by pertussis vaccine. surveillance and a nested serosurvey were conducted among infants in a large-scale evaluation of PRP-T in Santiago. Infants received either combined PRP-T/DTP or DTP only at 2. 4. and 6 months of age. At 8 months. pertussis agglutinin. anti-pertussis toxin. and anti-filamentous hemagglutinin antibody levels in the PRP-T/DTP (137.7. 23.1. and 12.2. respectively) and DTP (142.9.20.6. and 13.0. respectively) groups were comparable. The incidence of pertussis was similar among infants assigned to health centers administering combined PRP-TIDTP and those administering DTP alone (13.1 vs. 12.2 cases/105 child-years). Combined PRP-T/DTP vaccine did not diminish protection against pertussis.Keywords
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