Does Nitroglycerin Explode?

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Abstract
To the Editor: Systems for sustained, long-term transcutaneous administration of drugs are becoming increasingly popular. The most widely used of these are for the delivery of nitroglycerin. These are available as Transderm Nitro (CIBA) and Nitro-Dur (Key). Patients frequently apply them over the left chest so that they are close to the heart. This can cause an interesting problem, as described below.A 63-year-old woman had been followed for ischemic cardiomyopathy and angina after multiple myocardial infarctions, the most recent having occurred three weeks before her final presentation. She was being treated with Transderm Nitro (five daily), digoxin, furosemide, and . . .

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