The Clinical Investigation of a Codeine Resin Complex

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Abstract
THROUGHOUT the history of medicine, opium and its derivatives have been relied upon as proved pain suppressants. And, even today, codeine remains one of the most effective analgesics for oral administration despite the current use of several new synthetic substitutes in medical practice. It has been reported that some of the new synthetic analgesics do not cause addiction or habituation. The long-term effect of these new agents, particularly when they are used in high dosage over a long period, has not been completely assessed.An ultimate goal in the present search for an improved analgesic is the development of a . . .

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