Hemodynamic parameters and blood gas analyses in the normal and the cirrhotic rat

Abstract
Thioacetamide-fed rats developed cirrhosis with portal hypertension (P portal = 23.0 ± 5.2 cm H2O, controls: 14.4 ± 1.0 cm H2O). The PO2 of liver tissue was markedly reduced in cirrhosis (PO2 = 7.6 ± 3.4 torr, controls 22.3 ± 5.8 torr), and the aortal pH was significantly lower as well. No correlation was found between portal hypertension, development of large—nodular cirrhosis, and ascites.