The OxyR regulon
- 1 October 1990
- journal article
- review article
- Published by Springer Nature in Antonie van Leeuwenhoek
- Vol. 58 (3) , 157-161
- https://doi.org/10.1007/bf00548927
Abstract
Treatment of Salmonella typhimurium and Escherichia coli cells with low doses of hydrogen peroxide results in the induction of thirty proteins and resistance to killing by higher doses of hydrogen peroxide. The expression of nine of the hydrogen peroxide-inducible proteins, including catalase, glutathione reductase and a novel alkyl hydroperoxide reductase is controlled by the positive regulator oxyR. OxyR is homologous to the LysR-NodD family of bacterial regulatory proteins and binds to the promoters of oxyR-regulated genes. The oxidized but not reduced form of the OxyR protein activates transcription of oxyR-regulated genes in vitro suggesting that oxidation of the OxyR protein brings about a conformational change by which OxyR both senses and transduces an oxidative stress signal to RNA polymerase.Keywords
This publication has 21 references indexed in Scilit:
- Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases.Journal of Biological Chemistry, 1990
- Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by OxidationScience, 1990
- Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stressJournal of Molecular Biology, 1989
- OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.Proceedings of the National Academy of Sciences, 1989
- An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahpJournal of Bacteriology, 1989
- Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium.Proceedings of the National Academy of Sciences, 1987
- Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.Proceedings of the National Academy of Sciences, 1986
- Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.Proceedings of the National Academy of Sciences, 1986
- Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimuriumCell, 1985
- Inducible repair of oxidative DNA damage in Escherichia coliNature, 1983