The Effects of Bumetanide and Furosemide on Lung Liquid Secretion in Fetal Sheep

Publisher Website
Google Scholar
Abstract
Thirty-four experiments were carried out on the effects of loop diuretics on lung liquid secretion in 20 fetal sheep (128-145 days gestation) with indwelling catheters. Bumetanide placed in the lung liquid at 2.19 .+-. 0.52 .times. 10-4 M produced immediate reabsorption of fluid, and effects lasted 3 hr (n = 6). Bumetanide at 1.1 .+-. 0.17 .times. 10-5 M reduced secretion significantly for 2 hr (n = 4), but at 1.07 .+-. 0.06 .times. 10-6 M there was no clear effect (n = 6). Controls showed no significant change (n = 6). Furosemide was less effective. At 3.1 .+-. 0.07 .times. 10-3 M it produced an immediate reabsorption, which lasted 3 hr, but an 1.0 .+-. 0.04 .times. 10-4 M it increased secretion slightly (n = 4); controls showed no significant change (n = 6). The results are consistent with the presence of a chloride transport system, perhaps with sodium cotransport, as the major factor in fetal lung liquid secretion.