Computed Tomography of the Brain in Severe Hypoglycaemia

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Abstract
Computed tomographic (CT) findings in a case of extreme hypoglycemia induced by suicidal overdose of chlorpropamide were described. Brain lesions were preferentially localized along the boundary zones (watersheds) between the territories of the main cerebral arteries. Generalized brain damage occurred during severe hypoglycemia coma. Neuropathological changes in this condition were the subject of previous studies in experimental animals. CT allowed follow-up studies of the human brain damaged by hypoglycemic coma. Abnormalities revealed by CT probably represented reparative tissue reactions that indirectly reflected the extent of neuronal destruction.

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