Evidence for the Placental Origin of Hyaluronidase in the Maternal Circulation

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Abstract
The level of maternal serum hyaluronidase activity was shown to rise during pregnancy. Investigation of non-pregnant females did not demonstrate hormonal control of enzyme activity. The findings of a quantitative increase in serum hyaluronidase activity during pregnancy is presented in conjunction with previous evidence of a qualitative change in this enzyme as evidence for a placental origin of the increased activity demonstrated.

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