Bromobenzene Metabolism and Hepatic Necrosis

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Abstract
Treatment of rats with Phenobarbital stimulates the metabolism of bromobenzene and potentiates the hepatic necrosis elicited by the hydrocarbon. In contrast, administration of SKF 525-A or of piperonyl butoxide blocks bromobenzene metabolism and prevents the damage to the liver. These results indicate that the hepatotoxic effect of bromobenzene is mediated by a metabolite.

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