Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis
- 1 November 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (11) , 4137-4140
- https://doi.org/10.1128/aac.00196-08
Abstract
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis -infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.Keywords
This publication has 15 references indexed in Scilit:
- Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910Antimicrobial Agents and Chemotherapy, 2007
- Lymphadenitis as a major element of disease in the guinea pig model of tuberculosisTuberculosis, 2006
- Oxygen status of lung granulomas in Mycobacterium tuberculosis‐infected miceThe Journal of Pathology, 2006
- Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by AerosolInfection and Immunity, 2006
- New insights into the function of granulomas in human tuberculosisThe Journal of Pathology, 2005
- Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2005
- Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tensionCellular Microbiology, 2005
- Modified immunohistological staining allows detection of Ziehl–Neelsen‐negative Mycobacterium tuberculosis organisms and their precise localization in human tissueThe Journal of Pathology, 2005
- The Protective Effect of the Mycobacterium bovis BCG Vaccine Is Increased by Coadministration with the Mycobacterium tuberculosis 72-Kilodalton Fusion Polyprotein Mtb72F in M. tuberculosis -Infected Guinea PigsInfection and Immunity, 2004
- Immunopathogenesis of Pulmonary Granulomas in the Guinea Pig after Infection withMycobacterium tuberculosisInfection and Immunity, 2003