Heterocyclic studies. Part XXXVII. Ready ring cleavage and decarbonylation of pyrimidine-5-carbaldehydes
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 125-130
- https://doi.org/10.1039/p19760000125
Abstract
Treatment of 4-chloro-6-dialkylaminopyrimidine-5-carbaldehydes (4) with boiling water or dilute acetic or hydrochloric acid gave corresponding 3-dialkylamino-3-iminopropiononitriles (11) by ring cleavage and deformylation. The acid-catalysed deformylations, which followed ring cleavage, proceeded under extremely mild conditions and the formyl groups were lost as formic acid. Mechanisms for the ring cleavages and deformylations are proposed. 4-Chloro-6-monoalkylaminopyrimidine-5-carbaldehydes (16; X = CHO) under the same conditions underwent mainly simple hydrolysis of the chloro-substituent to give 6-alkylamino-5-formylpyrimidin-4(3H)-ones (17; X = CHO). Some other 4,6-disubstituted pyrimidine-5-carbaldehydes underwent deformylation without ring cleavage.Keywords
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