Genome‐wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

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Abstract
BACKGROUND The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early‐onset disease fulfilling criteria of ≥4 affected. METHODS We present a ∼10 cM genome‐wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores ≥1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome‐wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families ≥2.3 in this region. Twenty‐nine families with no‐male‐to‐male (MM) transmission gave a peak HLOD of 1.62 (α = 0.33) at the Xq21 locus. Two novel peaks ≥0.91 for the 16 families with ‘>6 affected’ occurred at 2p21 and 22q12. CONCLUSIONS These chromosomal regions in the genome warrant further follow‐up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families. Prostate 67:22–31, 2007.