The effect of geometry on capillary wall dose for boron neutron capture therapy

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Abstract
The 10B(n,.alpha.)7Li dose to endothelial cell regions of an 8.mu.m diameter capillary lies between 1/3 and 1/5 of the infinite blood pool dose depending on what average thickness is chosen to represent the cell. This estimate indicated that even for the case of equal B concentrations in human brain tumor and blood, the capillary received a substantially smaller absorbed dose than received by a tumor cell at the same site. These results should aid in the planning of a therapy trial since the dose to the microvasculature may be more accurately estimated from a measurement of the B concentration in blood and the activating neutron distribution.