A POSSIBLE PURINERGIC MECHANISM FOR REACTIVE ISCHEMIA IN ISOLATED, CROSS-CIRCULATED RAT KIDNEY

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Abstract
The isolated kidney of the recipient rat was perfused at a fixed flow rate with blood from a donor by a cross-circulation technique. The renal vasculature responded to the release of arterial occlusion with vasoconstriction; the magnitude was increased with increase in the duration of occlusion. ATP, ADP, AMP, adenosine, noradrenaline [norepinephrine] and 5-HT [serotonin] injected into the renal artery induced a prominent vasoconstriction. IMP and inosine had only a weak vasoconstrictor effect even in large doses. Theophylline reduced the vasoconstriction in response to arterial occlusion and to ATP and adenosine but did not affect that produced by noradrenaline or 5-HT. Apparently adenine compounds, particularly adenosine, may play a role in the genesis of reactive vasoconstriction after arterial occlusion in the isolated rat kidney.