β-Mercaptoethylamine Effect on Radiation Dose-Response Characteristics of Granulocyte and Lymphocyte Counts
- 1 September 1965
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 26 (1) , 146-+
- https://doi.org/10.2307/3571804
Abstract
Significant protective effects of MEA are demonstrated for lymphocyte counts as early as 2 days after irradiation and for granulocyte counts 3 and 4 days after irradiation. Granulocyte mobilization and MEA toxicity complicate the study of protective effects 1 and 2 days after MEA administration and irradiation. The dose-reduction factors estimated for early granulocyte and lymphocyte counts and for recovery counts 10 to 14 and 16 to 20 days after irradiation are in substantial agreement with each other and with the DRF for 28-day survival. When granulocyte counts had returned to normal, lymphocyte counts in both treated and untreated mice were still far below initial levels, and differences between the 2 groups had essentially disappeared. Without knowledge of the extent to which these counts are dose-dependent, dose-reduction factors could not be computed.This publication has 1 reference indexed in Scilit:
- Radiation Dose-Response Characteristics of Leucocytes in the MouseExperimental Biology and Medicine, 1962