ACQUIRED PATERNAL INFLUENCE IN MICE. ALTERED SERUM ANTIBODY RESPONSE IN THE PROGENY POPULATION OF IMMUNIZED CBA/H MALES

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Abstract
First generation offspring derived from CBA/H males immunized in adult life against rat blood cell antigens displayed altered immune reactivity to rat erythrocytes (RE) as assayed at a single lime point after challenge, For the low antigen challenge doses employed (106 to 107 RE i.p.) the population of test offspring showed a significant enhancement of serum antibody response relative to the control population of progeny of unimmunized males; at higher antigen challenge doses (108 RE i.p.) the response in the test progeny population was suppressed.