Lhx2 Maintains Stem Cell Character in Hair Follicles
Top Cited Papers
- 30 June 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 312 (5782) , 1946-1949
- https://doi.org/10.1126/science.1128004
Abstract
During embryogenesis, stem cells are set aside to fuel the postnatal hair cycle and repair the epidermis after injury. To define how hair follicle stem cells are specified and maintained in an undifferentiated state, we developed a strategy to isolate and transcriptionally profile embryonic hair progenitors in mice. We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors.Keywords
This publication has 32 references indexed in Scilit:
- Mapping stem cell activities in the feather follicleNature, 2005
- Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell CompartmentCurrent Biology, 2005
- A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in MiceScience, 2005
- Molecular principles of hair follicle induction and morphogenesisBioEssays, 2005
- Capturing and profiling adult hair follicle stem cellsNature Biotechnology, 2004
- Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IAThe Journal of cell biology, 2003
- Links between signal transduction, transcription and adhesion in epithelial bud developmentNature, 2003
- Getting under the skin of epidermal morphogenesisNature Reviews Genetics, 2002
- Sonic hedgehog signaling is essential for hair developmentCurrent Biology, 1998
- The secret life of the hair follicleTrends in Genetics, 1992