Effect of Adrenalectomy on Tryptophan Peroxidase, Adenosine Deaminase, And Arginase Content of Regenerating Rat Liver.

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Abstract
The concentration of tryptophan peroxidase in the livers of rats remained approximately normal one day after partial hepatectomy, and then decreased to half the control level on the 2nd day. In rats previously adrenalectomized, the activity dropped to a low value on the 1st day, an indication that in non-adrenalectomized rats the high activity on the first day was attributable to an adrenal adaptive or compensatory response. The maximum tryptophan peroxidase activity, produced by injection of tryptophan, was also markedly reduced after partial hepatectomy. After 7-10 days, the activity was within the normal range. The behavior of adenosine deaminase and arginase in regenerating liver was markedly different from that of tryptophan peroxidase, the former increasing and the latter remaining unchanged. Adrenalectomy decreased the resting value of arginase, but did not alter that of adenosine deaminase.