Prevention of immunoglobulin production by allotypedependent T cells
- 1 August 1978
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 8 (8) , 562-568
- https://doi.org/10.1002/eji.1830080805
Abstract
Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-lb. The apparent mediators of this Ig-lb barrier were T cells specific for Ig-lb determinants on B cells. Additional cell transfers showed Iga mice to have a second barrier against allotype production by Igd donor cells. Reciprocal cell transfers showed Igb and Igd mice to have comparatively weak barriers against Iga-producing cells. As host barriers were absent in mice deficient for T cells (athymic nude mice), it appears that they are T cell-mediated. Further, the allotype-dependence of such barriers means that the antigens responsible must be under the control of allotype-linked genes. The regulatory implications of this for the immune system are discussed.This publication has 37 references indexed in Scilit:
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