PHARMACOKINETIC INVESTIGATIONS WITH PENTA-ACETYL-GITOXIN-H-3 IN VOLUNTEERS AND PATIENTS WITH RESPECT TO OCCURRENCE OF DRUG LATENTIATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (6) , 285-289
Abstract
After oral administration of 3H-penta-acetyl-gitoxin (Pengitoxin W.H.O., Pentagit), [cardiovascular drug] 1.5 mg to 4 volunteers, serum radioactivity declines with a half-life of 62 .+-. 10 h. After an oral maintenance dose of 0.4 mg pengitoxin in 5 digitalized patients, 4 of them with a cannulated bile duct, serum radioactivity declines with a half-life of 56 .+-. 8 h. In volunteers, within 4 days 50.7% of the administered radioactivity is excreted in urine; in the patients 52.3% in urine and 28.0% in bile. By TLC studies, 16-acetyl-gitoxin was characterized as the main metabolite in serum, bile and urine. In the 1st 8 h after administration, 2 additional metabolites occur in urin.

This publication has 3 references indexed in Scilit: