β 2 -Adrenergic Receptor Gene Variation and Hypertension in Subjects With Type 2 Diabetes
- 1 May 2001
- journal article
- other
- Published by Wolters Kluwer Health in Hypertension
- Vol. 37 (5) , 1303-1308
- https://doi.org/10.1161/01.hyp.37.5.1303
Abstract
—The aim of this study was to investigate whether polymorphisms in the β2-adrenergic receptor gene (5′LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs. The association study included 291 hypertensive patients without type 2 diabetes, 124 hypertensive patients with type 2 diabetes, and 265 healthy control subjects from Sweden. In addition, normotensive sib pairs that were discordant for the Arg16Gly (72 pairs) and Gln27Glu (40 pairs) polymorphisms were identified in type 2 diabetes families from Finland. Genotyping was performed using polymerase chain reaction–restriction fragment-length polymorphism analysis. Homozygous carriers of the Arg16 allele had a significantly increased odds ratio (OR) for hypertension in patients with type 2 diabetes (OR 2.14; 95% confidence interval [CI], 1.05 to 4.33), particularly among lean (body mass index<27 kg/m2) patients (OR 3.47; 95% CI, 1.06...Keywords
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