Intramembrane proteolysis by presenilins
- 1 December 2000
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 1 (3) , 217-224
- https://doi.org/10.1038/35043065
Abstract
Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid β-peptide (Aβ) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating Aβ, and one of these may have been identified as presenilin — a discovery that paves the way for a more complete understanding of presenilin structure and function.Keywords
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