Acceleration of the growth of populations and of the multiplication of tetrathyridia of Mesocestoides corti Hoeppli, 1925 (Cestoda: Cyclophyllidea) by some cytostatic agents

1 January 1973

journal article
Published by Canadian Science Publishing in Canadian Journal of Zoology

Vol. 51 (1) , 83-90
https://doi.org/10.1139/z73-013

Abstract

Experiments with tetrathyridia of Mesocestoides corti implanted intraperitoneally into LDF₁, SEC, and SWR mice showed that a single injection of cyclophosphamide, 200 mg/kg 1 day after infection, increased the total biomass of tetrathyridial populations in mice dissected 50 days later by 50 to 200%. Similar, though less pronounced, increases in the total biomass of populations were produced by dactinomycin, 0.35 mg/kg once a week, for 4 to 6 weeks. The average size of individual tetrathyridia decreased despite a considerable increase in the total biomass of their populations.The parasiticides lucanthone, which inhibits the growth of Echinococcus multilocularis cysts, and quinacrine, which is inactive in this respect, accelerate the growth of the biomass of tetrathyridial populations much less than the cytostatic agents cyclophosphamide and dactinomycin.

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