SEPARATION OF THE BIOSYNTHESIS OF THE ANTIBIOTIC POLYPEPTIDE TYROCIDINE FROM PROTEIN BIOSYNTHESIS
- 1 July 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (1) , 175-181
- https://doi.org/10.1073/pnas.50.1.175
Abstract
The biosynthesis of tyiocidine and protein by Bacillus brevis were compared. Several compounds affect the processes independently indicating distinct differences. Chloramphenicol and puromycin effectively inhibited protein synthesis but had no effect on the formation of tyrocidine. Several analogues of amino-acids inhibited the biosynthesis of tyrocidine without affecting that of protein. Other amino-acid analogues inhibited the production of protein but not tyrocidine.Keywords
This publication has 19 references indexed in Scilit:
- Effect of chloromycetin and penicillin on the incorporation of amino acids into actinomycin and protein by Streptomyces antibioticusBiochemical and Biophysical Research Communications, 1962
- Biosynthesis of bacterial cell walls.1962
- Biosynthesis of saturated fatty acids.1961
- Biosynthesis of gramicidin S I. General characteristics of the process in growing cultures of Bacillus brevisBiochimica et Biophysica Acta, 1961
- AMINO ACID TRANSFER FROM AMINOACYL-RIBONUCLEIC ACIDS TO PROTEIN ON RIBOSOMES OF ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1961
- BIOGENESIS OF THE ACTINOMYCINS*Annals of the New York Academy of Sciences, 1960
- Antibiotic Production as a Function of Spore Formation in Bacillus licheniformisNature, 1959
- Reactivity of analogs with pancreatic tryptophan-activating enzymeArchives of Biochemistry and Biophysics, 1957
- Toxin Production by Clostridium parabotulinum Type AJournal of General Microbiology, 1956
- Sedimentation and diffusion of licheniformins A, B and C.1952