Activation and signaling of the p38 MAP kinase pathway
Top Cited Papers
Open Access
- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Cell Research
- Vol. 15 (1) , 11-18
- https://doi.org/10.1038/sj.cr.7290257
Abstract
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.Keywords
This publication has 113 references indexed in Scilit:
- The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppressionGene, 2004
- p38 MAPK signaling during murine preimplantation developmentDevelopmental Biology, 2004
- Identification of Stathmin as a Novel Substrate for p38 DeltaBiochemical and Biophysical Research Communications, 1998
- A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysThe EMBO Journal, 1997
- Reactivating Kinase/p38 Phosphorylates τ Protein In VitroJournal of Neurochemistry, 1997
- Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl ImidazolesBiochemical and Biophysical Research Communications, 1997
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationNature, 1997
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling PathwaysScience, 1997
- Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal NeuronsPublished by Elsevier ,1996
- A two-component system that regulates an osmosensing MAP kinase cascade in yeastNature, 1994