Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine – a model for studying the role of androgens in chemical carcinogenesis

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Abstract
CBA male mice treated with 1,2-dimethylhydrazine (DMH) developed high incidence (up to 97%) of pararenal angiosarcomas. Castration that preceeded DMH-treatment almost completely inhibited the induction of these tumors while castration that followed DMH-treatment had on influence on their development. Testosterone propionate (TP) was efficient in restoring the incidence of DMH-induced pararenal tumors in castrated males only when given simultaneously with DMH and was totally inefficient when given after the cessation of DMH-administration. Castrated CBA female mice developed 92% of pararenal angiosarcomas when they received combined treatment with DMH and TP; no such tumors appeared in the intact females treated with DMH alone. The incidence of pararenal tumors in males of different strains was as follows; CBA, 97%; (CBA .times. C57Bl)F1, 36%, C57Bl, 4%; C3H, 35%; BALB/c, 13%; C3HA, 7%.