Effect of 3-amino-1,2,4-triazole on the formation of triglyceride in liver slice.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (9) , 2283-2286
- https://doi.org/10.1248/cpb.25.2283
Abstract
In the liver of rats that received the herbicide 3-amino-1,2,4-triazole (AT 1 g/kg, i.p.), the incorporation of 14C-acetate into TG [triglycerides] decreased about 45% when compared with that of the control. The incorporation of 14C-palmitate into TG did not differ from controls. The incorporation of 14C-acetate into total fatty acid decreased about 30% in the liver of rats given AT. In in vitro experiments, the incorporation of 14C-acetate into TG was inhibited about 40% in the presence of 50 mM AT in incubation mixtures; the inhibition was dependent on the concentration of AT. Decrease of liver TG level at AT may be partly due to the inhibition of fatty acid synthesis in the liver.This publication has 7 references indexed in Scilit:
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