Abstract
The antithrombic activities of 70% methanol extract (I) obtained from Korean red ginseng (root of P. ginseng) were evaluated in the models of experimental disseminated intravascular coagulation (DIC) induced by [Escherichia coli] endotoxin or thrombin in rats, and in the in vitro models of blood platelet aggregation, agglutination of fibrinogen and activation of fibrinolytic system. In the coagulative system, I prevented the exchanges of values of clinical examination (blood platelet, fibrinogen and prothrombin time) at a dose of 500 mg/kg in rats on DIC induced by endotoxin or thrombin. I also inhibited the formation of fibrin thrombi in the renal glomeruli on the thrombin-induced DIC in rats. In the fibrinolytic system, I showed fibrinolytic activity in rats as determined by the euglobulin lysis time (ELT) assay. In the in vitro experiments, incubation of I in the plasminogen-containing fibrin plate promoted activation of urokinase action.

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