Pharmacological Study on Panax ginseng C.A. MEYER. I. Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (1)
Open Access
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 103 (12) , 1269-1277
- https://doi.org/10.1248/yakushi1947.103.12_1269
Abstract
The antithrombic activities of 70% methanol extract (I) obtained from Korean red ginseng (root of P. ginseng) were evaluated in the models of experimental disseminated intravascular coagulation (DIC) induced by [Escherichia coli] endotoxin or thrombin in rats, and in the in vitro models of blood platelet aggregation, agglutination of fibrinogen and activation of fibrinolytic system. In the coagulative system, I prevented the exchanges of values of clinical examination (blood platelet, fibrinogen and prothrombin time) at a dose of 500 mg/kg in rats on DIC induced by endotoxin or thrombin. I also inhibited the formation of fibrin thrombi in the renal glomeruli on the thrombin-induced DIC in rats. In the fibrinolytic system, I showed fibrinolytic activity in rats as determined by the euglobulin lysis time (ELT) assay. In the in vitro experiments, incubation of I in the plasminogen-containing fibrin plate promoted activation of urokinase action.Keywords
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