The Effect of the Cardioselective Beta Blocker Celiprolol on Pulmonary Function in Asthmatic Patients

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Abstract
The influence of single oral doses of 200 mg celiprolol, 100 mg atenolol, and 200 mg metoprolol on airway resistance (Raw) FEV1, VC, and MEF 50 was studied in a randomized double-blind crossover trial. Eighteen patients with hypertension and asthma, 14 men and 4 women, aged 43-75 years, took part. Pulmonary function tests were performed in the morning before treatment and 2 and 5 h after each treatment in the whole-body plethysmograph. The use of bronchodilators was not allowed during the 3 days. There was no significant change in airway resistance, FEV1, and MEF 50 after celiprolol and a slight increase of vital capacity at 2 h. After atenolol there was a decrease of FEV1 and MEF 50 at 5 h. Metoprolol caused an increase in resistance at 2 and 5 h and a fall in FEV1, VC, and MEF 50 at 2 and 5 h. Two patients required bronchodilator therapy after metoprolol and were excluded from evaluation. We conclude that celiprolol appears to be a safe drug in the treatment of asthmatic patients.

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