The Guillain-Barre syndrome. Definition, etiology, and review of 1,100 cases

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Abstract
Of the 1,100 cases of Guillain-Barre syndrome reviewed, 1/3 were found to be without demonstrable cause. The remaining 2/3 were found to be associated mostly with infectious diseases of all kinds, but allergies, endocrine disturbances, toxins, neoplasms, and a host of miscellaneous conditions were also found. These associations are not proved to be etiological in nature, and, frequently, a multiplicity of factors were implicated. Whether the Guillain-Barre syndrome is taken to be a specific entity of unknown etiology or denotes a nonspecific reaction of the nervous system to injury, a process of demyelination is the common pathological denominator.

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