Erythrocyte 2,3-DPG, PO250% and available O2during the early post-natal fall in hemoglobin in rabbits

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Abstract
Erythrocyte 2,3-DPG [2,3-diphosphoglycerate], PO2 50% [O2 partial pressure at 50% saturation of Hb], whole blood Hb, available O2 and fixed acid Bohr effect were studied during the first 10 days after birth in rapidly growing suckling rabbits. The postnatal fall in Hb concentration was accompanied by a marked rise in erythrocyte 2,3-DPG and a gradual increase in PO2 50%. The rise in PO2 50% was sufficient to keep the available O2 of the blood unchanged throughout the observation period. A 2,3-DPG mediated rise in PO2 50% very effectively contributes to maintenance of adequate tissue oxygenation during the postnatal fall in Hb. The rise in 2,3-DPG and PO2 50% may be due to the ordinary hypoxia-induced shift to the right of the Hb O2 dissociation curve, as observed under other circumstances when blood Hb is rapidly reduced, but the very marked rise in 2,3-DPG and the very low .DELTA. PO2 50%/.DELTA. 2,3-DPG ratio suggest that the rise may as well be due to hypoxia-independent, preprogrammed processes. The fixed acid Bohr effect was essentially the same in newborn and adult rabbits and was uninfluenced by large variations in 2,3-DPG.

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