Survival of Heterologous Mammalian Transplants

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Abstract
In guinea-pigs, rabbits, and man, the rejection of living endocrine tissue transplants from other species of mammals (man, dog, monkey) can be avoided by implanting the tissue in diffusion chambers. The tissue will survive for long periods. In time the diffusion chambers become clogged and the transplant starves and ultimately (in a year or less) dies. After the transplant has been in residence in the host animal for 25 to 35 days if acquires chemical adjustment to the host. The filter of the diffusion chamber can now be broken by puncturing and slitting it. Now the transplant can be nourished by open access to the host''s fluids. If the openings made in the filter are large enough to permit it, granulation tissue and blood vessels of the host will vascularize the well preserved tissue of the transplant. There has been no evidence that the transplants cause any adverse effects on the host other than the normal reaction to small wound. The technical methods used are described in detail.

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