Biological Action of Small Deficiencies of X-Chromosome of Drosophila melanogaster
- 1 June 1934
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 20 (6) , 354-359
- https://doi.org/10.1073/pnas.20.6.354
Abstract
24 small deficiencies[long dash]some probably single locus deficiencies[long dash]affecting 11 regions of the X-chromosome were studied By a method found by Stern, small patches of cells homozygous for deficiency may be produced on otherwise normal individuals. Since these patches arise from somatic segregation, the position of each of them is marked by another patch of approximately equal size occurring adjacent to it and carrying the non-de-ficient chromosome. If the deficiency is lethal even to a few cells (cell-lethal), the spots with the deficiency would not appear. Ten regions were found to be cell-lethal. This indicates that genes in these regions are essential in vital cell functions.This publication has 3 references indexed in Scilit:
- A FURTHER STUDY OF THE SO-CALLED MUTATION AT THE BAR LOCUS OF DROSOPHILAGenetics, 1928
- Elimination of Chromosomes Due to a Mutant (Minute-N) in Drosophila MelanogasterProceedings of the National Academy of Sciences, 1925