In vitro Study on the Mechanisms of Action of Fluoride in Low Concentrations

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Abstract
The mechanisms of action of fluoride ions in saliva-sucrose solutions were studied when half crowns of premolars were employed in an in vitro system. The fluoride ion concentration of 0.9 ppm in the saliva-sucrose solutions decreased when teeth were stored in the solutions. The fluoride which was removed from the solutions during acid exposure was found to be taken up by the teeth. The fluoride ion concentration of 0.9 ppm had no significant effect on the final pH values of the solutions in either the absence or presence of teeth. When fluoride had been added to the solutions, the release of calcium from the exposed surfaces was significantly reduced. Judging from paired comparisons of the pH and the calcium values, the reduced release of calcium in the presence of fluoride does not seem to be due to a pH alteration. The increased fluoride ion activity in the saliva-sucrose solution may explain the reduced dissolution of enamel by a redeposition of fluoridated enamel.

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