Biomagnification of cycad neurotoxins in flying foxes
Top Cited Papers
- 12 August 2003
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 61 (3) , 387-389
- https://doi.org/10.1212/01.wnl.0000078320.18564.9f
Abstract
β-Methylamino-l-alanine (BMAA) occurs in higher levels in museum specimens of the Guamanian flying fox than in the cycad seeds the flying foxes feed on, confirming the hypothesis that cycad neurotoxins are biomagnified within the Guam ecosystem. Consumption of a single flying fox may have resulted in an equivalent BMAA dose obtained from eating 174 to 1,014 kg of processed cycad flour. Traditional feasting on flying foxes may be related to the prevalence of neuropathologic disease in Guam.Keywords
This publication has 9 references indexed in Scilit:
- Conservation Implications of Chamorro Consumption of Flying Foxes as a Possible Cause of Amyotrophic Lateral Sclerosis–Parkinsonism Dementia Complex in GuamConservation Biology, 2003
- Isolation of various forms of sterol β‐d‐glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS‐parkinsonism dementia complexJournal of Neurochemistry, 2002
- Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in GuamNeurology, 2002
- Synthesis of a Fluorescent Derivatizing Reagent, 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate, and Its Application for the Analysis of Hydrolysate Amino Acids via High-Performance Liquid ChromatographyAnalytical Biochemistry, 1993
- Content of the neurotoxins cycasin (methylazoxymethanol β‐D‐glucoside) and BNLAA (β‐ N ‐methylamino‐L‐alanine) in cycad flour prepared by Guam ChamorrosNeurology, 1992
- 2‐Amino‐3‐(methylamino)‐propanoic acid (BMAA) in cycad flourNeurology, 1990
- Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant NeurotoxinScience, 1987
- A COHORT STUDY OF AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA ON GUAM AND ROTAAmerican Journal of Epidemiology, 1987
- Epidemiologic Investigations of Amyotrophic Lateral SclerosisNeurology, 1954