The Susceptibility to Fungal Attack in Vitro of Different Parts of Hair Shafts from Griseofulvin-Treated Patients

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Abstract
Hairs from 25 boys, who were successfully treated by Griseofulvin for tinea capitis infection were compared with "control" hairs, in their susceptibility to hair penetration in vitro by Trichophyton mentagrophytes. A significantly increased resistance to fungal attack is displayed by the proximal halves of hair shafts from Griseofulvin-treated subjects compared with those from normal children. No such difference is seen when the distal halves of hair shafts are compared. An indirect evidence is adduced to confirm the view that Griseofulvin after oral ingestion becomes incorporated in hair keratin and produces resistance to hair penetration.

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