All‐D‐magainin: chirality, antimicrobial activity and proteolytic resistance
- 12 November 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 274 (1-2) , 151-155
- https://doi.org/10.1016/0014-5793(90)81351-n
Abstract
All‐D‐magainin‐2 was synthesized to corroborate experimentally the notion that the biological function of a surface‐active peptide stems primarily from its unique amphiphilic α ‐helical structure. Indeed, the peptide exhibited antibacterial potency nearly identical to that of the all‐L‐enantiomer. Being highly resistant to proteolysis and non‐hemolytic all‐D‐magainin might have considerable therapeutic importance.Keywords
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