UVEORETINITIS AND PINEALITIS INDUCED BY IMMUNIZATION WITH INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN
- 1 August 1986
- journal article
- research article
- Vol. 27 (8) , 1296-1300
Abstract
Rats immunized with microgram amounts of interphotoreceptor retinoid-binding porotein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by Bordetella pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.This publication has 7 references indexed in Scilit:
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